Description

  • Product name

    Recombinant human PPP1CB (ab128551)
  • Biological activity

    The specific activity of ab128551 was determined to be 272 nmol/min/mg
  • Purity

    > 70 % Densitometry.

  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      60 kDa including tags
    • Amino acids

      1 to 327
    • Tags

      GST tag N-Terminus
  • Description

    Recombinant human PPP1CB protein

Associated products

Specifications

Our Abpromise guarantee covers the use of ab128551 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Phosphatase Activity

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Centrifuge before aliquoting into smaller quantities.

     This product was previously labelled as Protein Phosphatase 1 beta, PPP1CA + 1CB

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.02% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • MGC3672
    • PP 1B
    • PP-1B
    • PP1B
    • PP1B_HUMAN
    • PP1beta
    • PPP1CB
    • PPP1CD
    • Protein phosphatase 1 beta
    • Protein phosphatase 1 catalytic subunit beta isoform
    • Protein phosphatase 1 delta
    • Protein phosphatase 1, catalytic subunit, beta isozyme
    • Protein phosphatase 1, catalytic subunit, delta isoform
    • Serine threonine protein phosphatase PP1 beta catalytic subunit
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    see all
  • Function

    Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • Sequence similarities

    Belongs to the PPP phosphatase family. PP-1 subfamily.
  • Cellular localization

    Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt

Images

  • Recombinant human PPP1CB (ab128551) (ab128551)
  • Phosphatase activity demonstrating specific activity of ab128551.

References

ab128551 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab128551.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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