Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRH FVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHV FSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRS HFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVD CVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNND GQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGL FPEWQSWGRMENLASYR
    • Molecular weight

      61 kDa including tags
    • Amino acids

      1 to 317

Specifications

Our Abpromise guarantee covers the use of ab132749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.

    Previously labelled as Protein phosphatase 1 inhibitor 3C.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • OTTHUMP00000020089
    • Phosphatase 1, regulatory inhibitor subunit 5
    • PP1 subunit R5
    • ppp1r3c
    • PPP1R5
    • PPR3C_HUMAN
    • Protein phosphatase 1 inhibitor 3C
    • Protein phosphatase 1 regulatory subunit 3C
    • Protein phosphatase 1 regulatory subunit 5
    • protein phosphatase 1, regulatory (inhibitor) subunit 3C
    • Protein targeting to glycogen
    • PTG
    • R5
    see all
  • Function

    Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
  • Sequence similarities

    Contains 1 CBM21 (carbohydrate binding type-21) domain.
  • Domain

    The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
  • Post-translational
    modifications

    Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
  • Information by UniProt

Images

  • ab132749 on 12.5% SDS-PAGE stained with Coomassie blue.

References

ab132749 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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