- Datasheet
- Specific References
- Protocols
Overview
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Product nameRecombinant Human proCathepsin D protein
See all proCathepsin D proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceHEK 293 cells
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceSALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIP EVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACW IHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASA LGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNL MQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKA YWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAV PLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLS GFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARLVDHHHH HH
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Molecular weight44 kDa including tags
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Amino acids19 to 412
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TagsHis tag C-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab151860 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
HPLC
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Endotoxin level< 1.000 Eu/µg
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Purity>95% by SDS-PAGE .
Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
ab151860 has been 0.2 µM filtered. -
FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 5.50
Constituents: 0.39% MES, 0.88% Sodium chloride
General Info
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Alternative names
- CATD_HUMAN
- Cathepsin D
- cathepsin D (lysosomal aspartyl protease)
see all -
FunctionAcid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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Involvement in diseaseDefects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
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Sequence similaritiesBelongs to the peptidase A1 family.
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Cellular localizationLysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
References
ab151860 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
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