Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab126698)

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SDS-PAGE - Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab126698)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: MS, SDS-PAGE

    Description

    • Product name

      Recombinant Human Prostaglandin D Synthase (hematopoietic) protein
      See all Prostaglandin D Synthase (hematopoietic) proteins and peptides

    • Purity

      > 95 % SDS-PAGE.
      ab126698 is purified by conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      O60760

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSHMPNYKL TYFNMRGRAE IIRYIFAYLD IQYEDHRIEQ ADWPEIKSTL PFGKIPILEV DGLTLHQSLA IARYLTKNTD LAGNTEMEQC HVDAIVDTLD DFMSCFPWAE KKQDVKEQMF NELLTYNAPH LMQDLDTYLG GREWLIGNSV TWADFYWEIC STTLLVFKPD LLDNHPRLVT LRKKVQAIPA VANWIKRRPQ TKL

      • Predicted molecular weight

        26 kDa including tags

      • Amino acids

        1 to 199

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab126698 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Mass Spectrometry

      SDS-PAGE

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

    General Info

    • Alternative names

      • Cerebrin 28
      • Glutathione dependent PGD synthetase
      • Glutathione S-transferase
      • Glutathione-dependent PGD synthase
      • Glutathione-requiring prostaglandin D synthase
      • GST class-sigma
      • H PGDS
      • H-PGDS
      • Haematopoietic prostaglandin D synthase
      • Haematopoietic prostaglandin D2 synthase
      • Hematopoietic prostaglandin D synthase
      • Hpgds
      • HPGDS_HUMAN
      • Prostaglandin D synthase
      • Prostaglandin D2 synthase hematopoietic
      • Prostaglandin H2 D isomerase
      • Prostaglandin-H2 D-isomerase
      • PTGDS2
      see all

    • Function

      Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

    • Tissue specificity

      Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.

    • Sequence similarities

      Belongs to the GST superfamily. Sigma family.
      Contains 1 GST C-terminal domain.
      Contains 1 GST N-terminal domain.

    • Developmental stage

      Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab126698)
      SDS-PAGE - Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab126698)
      15% SDS-PAGE analysis of 3 µg of ab126698 (Prostaglandin D Synthase (hematopoietic) protein).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab126698? Please let us know so that we can cite the reference in this datasheet.

    ab126698 has not yet been referenced specifically in any publications.

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