Recombinant Human Prostaglandin D Synthase (hematopoietic) protein (ab126698)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      O60760
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSHMPNYKL TYFNMRGRAE IIRYIFAYLD IQYEDHRIEQ ADWPEIKSTL PFGKIPILEV DGLTLHQSLA IARYLTKNTD LAGNTEMEQC HVDAIVDTLD DFMSCFPWAE KKQDVKEQMF NELLTYNAPH LMQDLDTYLG GREWLIGNSV TWADFYWEIC STTLLVFKPD LLDNHPRLVT LRKKVQAIPA VANWIKRRPQ TKL
    • Molecular weight
      26 kDa including tags
    • Amino acids
      1 to 199
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    ab126698 is purified by conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • Cerebrin 28
    • Glutathione dependent PGD synthetase
    • Glutathione S-transferase
    • Glutathione-dependent PGD synthase
    • Glutathione-requiring prostaglandin D synthase
    • GST class-sigma
    • H PGDS
    • H-PGDS
    • Haematopoietic prostaglandin D synthase
    • Haematopoietic prostaglandin D2 synthase
    • Hematopoietic prostaglandin D synthase
    • Hpgds
    • HPGDS_HUMAN
    • Prostaglandin D synthase
    • Prostaglandin D2 synthase hematopoietic
    • Prostaglandin H2 D isomerase
    • Prostaglandin-H2 D-isomerase
    • PTGDS2
    see all
  • Function
    Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
  • Tissue specificity
    Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.
  • Sequence similarities
    Belongs to the GST superfamily. Sigma family.
    Contains 1 GST C-terminal domain.
    Contains 1 GST N-terminal domain.
  • Developmental stage
    Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Prostaglandin D Synthase (hematopoietic) protein (His tag) (ab126698)
    SDS-PAGE - Prostaglandin D Synthase (hematopoietic) protein (His tag) (ab126698)
    15% SDS-PAGE analysis of 3 µg of ab126698 (Prostaglandin D Synthase (hematopoietic) protein).

References

ab126698 has not yet been referenced specifically in any publications.

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