The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
>95% by SDS-PAGE . Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. ab172856 is 0.2 µM filtered.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.00 Constituents: 1.17% Sodium chloride, 0.24% Tris
Glutathione dependent PGD synthetase
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
Haematopoietic prostaglandin D synthase
Haematopoietic prostaglandin D2 synthase
Hematopoietic prostaglandin D synthase
Prostaglandin D synthase
Prostaglandin D2 synthase hematopoietic
Prostaglandin H2 D isomerase
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.
Belongs to the GST superfamily. Sigma family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.
Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets.