Recombinant Human PRPF31 protein (ab131853)
Key features and details
- Expression system: Wheat germ
- Suitable for: SDS-PAGE, WB, ELISA
Description
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Product name
Recombinant Human PRPF31 protein -
Expression system
Wheat germ -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKT IAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLT VEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCK NNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNAS KHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIM LLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCT LAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQ RKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLG KSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTAS SVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST -
Predicted molecular weight
82 kDa including tags -
Amino acids
1 to 499
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Specifications
Our Abpromise guarantee covers the use of ab131853 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Western blot
ELISA
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- DKFZp566J153
- hPrp 31
- hPrp31
see all -
Function
Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation. -
Tissue specificity
Ubiquitously expressed. -
Involvement in disease
Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant. -
Sequence similarities
Belongs to the PRP31 family.
Contains 1 Nop domain. -
Domain
Interacts with the snRNP via the Nop domain.
The coiled coil domain is formed by two non-contiguous helices. -
Cellular localization
Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab131853 has not yet been referenced specifically in any publications.