The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
NY BR 99
Pre mRNA processing factor 31
Pre mRNA processing factor 31 homolog
Pre mRNA processing factor 31 homolog (yeast)
Pre-mRNA-processing factor 31
Precursor mRNA-processing factor 31, S. cerevisiae, homolog of
PRP31 pre mRNA processing factor 31 homolog
PRP31 pre mRNA processing factor 31 homolog (yeast)
Serologically defined breast cancer antigen NY BR 99
Serologically defined breast cancer antigen NY-BR-99
U4/U6 small nuclear ribonucleoprotein Prp31
U4/U6 snRNP 61 kDa protein
Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
Involvement in disease
Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
Belongs to the PRP31 family. Contains 1 Nop domain.
Interacts with the snRNP via the Nop domain. The coiled coil domain is formed by two non-contiguous helices.
Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.