Recombinant Human PSD95 protein (ab131874)

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SDS-PAGE - Recombinant Human PSD95 protein (ab131874)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, WB, SDS-PAGE

    Description

    • Product name

      Recombinant Human PSD95 protein
      See all PSD95 proteins and peptides

    • Expression system

      Wheat germ

    • Accession

      P78352-2

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLS ESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGT EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQ DGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEK VMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQ IGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDI PREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGD QILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDL REQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFG DVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDW GSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPD KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLEN VLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRV IEDLSGPYIWVPARERL

      • Predicted molecular weight

        112 kDa including tags

      • Amino acids

        1 to 767

    Specifications

    Our Abpromise guarantee covers the use of ab131874 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Discs large homolog 4
      • Disks large homolog 4
      • DLG 4
      • Dlg4
      • DLG4_HUMAN
      • FLJ97752
      • FLJ98574
      • Human post synaptic density protein 95
      • Post synaptic density protein 95
      • Postsynaptic density protein 95
      • PSD 95
      • PSD-95
      • PSD95
      • SAP 90
      • SAP-90
      • SAP90
      • Synapse associated protein 90
      • Synapse-associated protein 90
      • Tax interaction protein 15
      see all

    • Function

      Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

    • Tissue specificity

      Brain.

    • Sequence similarities

      Belongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 3 PDZ (DHR) domains.
      Contains 1 SH3 domain.

    • Domain

      The PDZ domain 3 mediates interaction with ADR1B.
      The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.

    • Post-translational
      modifications

      Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

    • Cellular localization

      Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human PSD95 protein (ab131874)
      SDS-PAGE - Recombinant Human PSD95 protein (ab131874)
      12.5% SDS-PAGE analysis of ab131874 stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab131874? Please let us know so that we can cite the reference in this datasheet.

    ab131874 has not yet been referenced specifically in any publications.

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