Description

  • Product name

    Recombinant human PSME1 protein
    See all PSME1 proteins and peptides
  • Biological activity

    Activation of 5 nM 20S proteasome by 25 nM ab206168, the proteasome activity was assayed by using 50 µM Suc-LLVY-AMC as the substrate. The AMC fluorescence was monitored by a plate reader with excitation and emission filters of 360±40 nm and 460±30 nm, respectively.

  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALN EANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPP CGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGV AVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQL VHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
    • Predicted molecular weight

      29 kDa
    • Amino acids

      1 to 249
    • Additional sequence information

      (NM_006263).

Specifications

Our Abpromise guarantee covers the use of ab206168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    Constituents: 0.24% Tris, 0.87% Sodium chloride, 0.02% Beta mercaptoethanol, 10% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 11S regulator complex alpha subunit
    • 11S regulator complex subunit alpha
    • 29 kD MCP activator subunit
    • 29kD MCP activator subunit
    • Activator of multicatalytic protease subunit 1
    • IFI5111
    • IGUP I-5111
    • Interferon gamma IEF SSP 5111
    • Interferon gamma inducible protein 5111
    • Interferon gamma up regulated I 5111 protein
    • Interferon gamma up-regulated I-5111 protein
    • MGC8628
    • PA28a
    • PA28alpha
    • Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
    • Proteasome activator 28 subunit alpha
    • Proteasome activator complex subunit 1
    • Proteasome activator subunit 1
    • PSME1
    • PSME1_HUMAN
    • REG-alpha
    • REGalpha
    see all
  • Function

    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
  • Sequence similarities

    Belongs to the PA28 family.
  • Information by UniProt

Images

  • Functional analysiss of ab206168. Activation of 5 nM 20S proteasome by 25 nM ab206168, the proteasome activity was assayed by using 50 µM Suc-LLVY-AMC as the substrate. The AMC fluorescence was monitored by a plate reader with excitation and emission filters of 360±40 nm and 460±30 nm, respectively.

  • Coomassie-stained SDS-PAGE analysis of  ab206168 (5µg).

References

ab206168 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab206168.
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