The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
patched (Drosophila) homolog 2
patched homolog 2 (Drosophila)
Protein patched homolog 2
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
Involvement in disease
Defects in PTCH2 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome). Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462].
Belongs to the patched family. Contains 1 SSD (sterol-sensing) domain.