The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 1.000 Eu/µg
>95% by SDS-PAGE . Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Supplied as a 0.2 µM filtered solution.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.50 Constituent: 0.3% Tris
Non receptor tyrosine phosphatase 1
Protein phosphotyrosylphosphatase 1B
Protein tyrosine phosphatase 1B
Protein tyrosine phosphatase non receptor type 1
Protein tyrosine phosphatase placental
Protein-tyrosine phosphatase 1B
Tyrosine protein phosphatase non receptor type 1
Tyrosine-protein phosphatase non-receptor type 1
May play an important role in CKII- and p60c-src-induced signal transduction cascades.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. Contains 1 tyrosine-protein phosphatase domain.
Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.