Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      NRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYD KAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHC VAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRP KMRLRFRDTNGHCCVQ
    • Molecular weight
      19 kDa including tags
    • Amino acids
      2 to 167
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab157062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    0.334U/µg. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37°C. Assay buffer: 50mM TRIS, pH 7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    >90% by SDS-PAGE.

  • Form
    Liquid
  • Additional notes
    0.334U/µg. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37°C. Assay buffer: 50mM TRIS, pH 7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.05% DTT, 0.39% Tris HCl, 0.05% Tween, 20% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • BM 008
    • EC 3.1.3.48
    • HH 13
    • HH13
    • HH7 2
    • HU PP 1
    • HUPP 1
    • HUPP1
    • OV 1
    • OV1
    • phosphatase of regenerating liver 2
    • PRL 2
    • PRL2
    • Protein tyrosine phosphatase 4a2
    • protein tyrosine phosphatase IVA
    • protein tyrosine phosphatase IVA2
    • Protein tyrosine phosphatase of regenerating liver 2
    • protein tyrosine phosphatase type IVA 2
    • Protein tyrosine phosphatase type IVA member 2 isoform 1
    • protein tyrosine phosphatase type IVA, member 2
    • PTP (CAAXII)
    • ptp IV1a
    • ptp IV1b
    • PTP4A
    • PTPCAAX2
    • TP4A2_HUMAN
    see all
  • Relevance
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
  • Cellular localization
    Cell Membrane, Early Endosome and Cytoplasm.

References

ab157062 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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