Product nameRecombinant Human PTP4A3/PRL-R protein
Purity> 95 % SDS-PAGE.
ab87716 is purified using conventional chromatography techniques. Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method).
Expression systemEscherichia coli
Protein lengthFull length protein
SequenceMGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM
Our Abpromise guarantee covers the use of ab87716 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Previously labelled as PTP4A3.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol
- Potentially prenylated protein tyrosine phosphatase
- PRL 3
- PRL R
FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Tissue specificityMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.
modificationsFarnesylated. Farnesylation is required for membrane targeting.
Cellular localizationCell membrane. Early endosome.
- Information by UniProt
15% SDS-PAGE showing ab87716 at approximately 21.6kDa (3µg).
All lanes : Anti-PTP4A3/PRL-R antibody (ab82568) at 1 µg/ml
Lane 1 :
Recombinant Human PTP4A3/PRL-R protein (ab87716) at 0.01 µg
Lane 2 :
Recombinant Human PTP4A3/PRL-R protein (ab87716) at 0.1 µg
All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Exposure time: 20 seconds
ab87716 has not yet been referenced specifically in any publications.