Description

  • Product name

    Recombinant Human PTP4A3/PRL-R protein
  • Purity

    > 95 % SDS-PAGE.
    ab87716 is purified using conventional chromatography techniques. Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method).
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

Specifications

Our Abpromise guarantee covers the use of ab87716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Previously labelled as PTP4A3. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • Potentially prenylated protein tyrosine phosphatase
    • PRL 3
    • PRL R
    • PRL-3
    • PRL-R
    • PRL3
    • PRLR
    • Protein tyrosine phosphatase 4a3
    • Protein tyrosine phosphatase type IVA 3
    • Protein-tyrosine phosphatase 4a3
    • Protein-tyrosine phosphatase of regenerating liver 3
    • PTP 4A3
    • PTP4A3
    • TP4A3_HUMAN
    see all
  • Function

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • Tissue specificity

    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications

    Farnesylated. Farnesylation is required for membrane targeting.
  • Cellular localization

    Cell membrane. Early endosome.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab87716 at approximately 21.6kDa (3µg).
  • All lanes : Anti-PTP4A3/PRL-R antibody (ab82568) at 1 µg/ml

    Lane 1 : Recombinant Human PTP4A3/PRL-R protein (ab87716) at 0.01 µg
    Lane 2 : Recombinant Human PTP4A3/PRL-R protein (ab87716) at 0.1 µg

    Secondary
    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Exposure time: 20 seconds

References

ab87716 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab87716.
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