Recombinant Human PTPIA2 / PTPRN protein (ab42590)

Overview

  • Product name
    Recombinant Human PTPIA2 / PTPRN protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      59 kDa including tags
    • Amino acids
      693 to 979
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab42590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Phosphatase Activity

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes


    This protein may be useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.307% Glutathione, 0.0154% DTT, 0.395% Tris HCl, 0.05% Tween, 0.0584% EDTA, 50% Glycerol, 0.435% Sodium chloride

General Info

  • Alternative names
    • CA 512
    • FLJ16131
    • IA 2
    • IA 2/PTP
    • IA2
    • IA2/PTP
    • ICA 3
    • ICA 512
    • ICA3
    • ICA512
    • Islet cell antigen 2
    • Islet cell antigen 512
    • Islet cell autoantigen 3
    • Protein tyrosine phosphatase like N
    • Protein tyrosine phosphatase like N precursor
    • Protein tyrosine phosphatase receptor type N
    • PTP IA 2
    • PTP IA-2
    • PTP IA2
    • PTPIA 2
    • PTPN
    • Ptprn
    • PTPRN protein
    • PTPRN_HUMAN
    • R PTP N
    • R-PTP-N
    • Receptor type tyrosine protein phosphatase like N
    • Receptor-type tyrosine-protein phosphatase-like N
    • RPTPN
    see all
  • Function
    Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
  • Tissue specificity
    Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
  • Cellular localization
    Membrane. Neuroendocrine secretory granules.
  • Information by UniProt

References

ab42590 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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