lymphoid-specific, inducible human protein tyrosine phosphatase
Protein tyrosine phosphatase non receptor type 22
Protein tyrosine phosphatase non receptor type 22 (lymphoid)
Protein tyrosine phosphatase non receptor type 8
Protein tyrosine phosphatase non receptor type 8, formerly
Tyrosine-protein phosphatase non-receptor type 22
Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.
Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.