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    recombinant-human-pyrin-protein-ab158876.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Recombinant Human Pyrin protein (ab158876)

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SDS-PAGE - Recombinant Human Pyrin protein (ab158876)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    Description

    • Product name

      Recombinant Human Pyrin protein
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MAKTPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARP VKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQEYSTQENG TDDSAASSSL
      • Amino acids

        1 to 110
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab158876 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • FMF
      • Marenostrin
      • Mediterranean fever
      • Mediterranean fever protein
      • MEF
      • Mefv
      • MEFV_HUMAN
      • Pyrin
      • TRIM20
      see all
    • Function

      Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.
    • Tissue specificity

      Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
    • Involvement in disease

      Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:249100]. ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence.
      Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:134610]. ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness.
    • Sequence similarities

      Contains 1 B box-type zinc finger.
      Contains 1 B30.2/SPRY domain.
      Contains 1 DAPIN domain.
    • Developmental stage

      First detected in bone marrow promyelocytes. Expression increases throughout myelocyte differentiation and peaks in the mature myelomonocytic cells.
    • Cellular localization

      Nucleus and Cytoplasm > cytoskeleton. Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles.
    • Target information above from: UniProt accession O15553 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Pyrin protein (ab158876)
      SDS-PAGE - Recombinant Human Pyrin protein (ab158876)
      ab158876 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab158876? Please let us know so that we can cite the reference in this datasheet.

    ab158876 has not yet been referenced specifically in any publications.

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