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Tags & Cell Markers Subcellular Markers Organelles Lysosome
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Recombinant Human RAB7B protein (ab166249)

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SDS-PAGE - Recombinant Human RAB7B protein (ab166249)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human RAB7B protein
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKII ILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALD IWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYF EVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC
      • Amino acids

        1 to 199
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab166249 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • MGC16212
      • MGC9726
      • RAB7
      • rab7B
      • RAB7B, member RAS oncogene family
      • RAB7B_HUMAN
      • Ras related protein Rab 7b
      • Ras-related protein Rab-7B
      see all
    • Function

      Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
    • Tissue specificity

      Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
    • Sequence similarities

      Belongs to the small GTPase superfamily. Rab family.
    • Cellular localization

      Late endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
    • Target information above from: UniProt accession Q96AH8 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human RAB7B protein (ab166249)
      SDS-PAGE - Recombinant Human RAB7B protein (ab166249)
      ab166249 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab166249? Please let us know so that we can cite the reference in this datasheet.

    ab166249 has not yet been referenced specifically in any publications.

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