Recombinant Human RAB7B protein (ab166249)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human RAB7B protein -
Expression system
Wheat germ -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKII ILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALD IWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYF EVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC -
Amino acids
1 to 199 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab166249 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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Form
Liquid -
Additional notes
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- MGC16212
- MGC9726
- RAB7
see all -
Function
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. -
Tissue specificity
Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte. -
Sequence similarities
Belongs to the small GTPase superfamily. Rab family. -
Cellular localization
Late endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human RAB7B protein (ab166249)ab166249 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab166249 has not yet been referenced specifically in any publications.
