Key features and details
- Expression system: Escherichia coli
- Purity: > 70% SDS-PAGE
- Active: Yes
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
Product nameRecombinant human RAC2 protein (Active)
See all RAC2 proteins and peptides
The specific activity was determined to be 13.5 nmol/min/mg in a GTPase-Glo assay using GTP solution substrate.
Purity> 70 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthFull length protein
Molecular weight informationSDS-PAGE molecular weight: ~22kDa.
TagsHis tag N-Terminus
Additional sequence informationGenBank: NM_002872
Our Abpromise guarantee covers the use of ab268913 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Preservative: 1.02% Imidazole
Constituents: 0.82% Sodium phosphate, 1.74% Sodium chloride, 0.002% PMSF, 0.004% DTT, 25% Glycerol (glycerin, glycerine)
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- EN 7
FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue specificityHematopoietic specific.
Involvement in diseaseDefects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:608203].
Sequence similaritiesBelongs to the small GTPase superfamily. Rho family.
Cellular localizationCytoplasm. Membrane-associated when activated.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab268913 has not yet been referenced specifically in any publications.