Description

  • Product name

    Recombinant Human Ran (mutated T24 N) protein
    See all Ran proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Protein preparation is 18% GDP-loaded, measured by HPLC.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Modifications

      mutated T24N

Associated products

Specifications

Our Abpromise guarantee covers the use of ab90206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes


    Ran T24N mutation results in no or little binding to GTP and is known to act as a negative inhibitor of nuclear import.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Constituents: 0.1001% DTE (1,4-Dithioerythritol), 1.125% Potassium chloride, 0.42% Potassium phosphate, 0.0475% Magnesium chloride, 10% Glycerol

General Info

  • Alternative names

    • Androgen receptor associated protein 24
    • Androgen receptor-associated protein 24
    • ARA 24
    • ARA24
    • Gsp1
    • GTP binding nuclear protein RAN
    • GTP-binding nuclear protein Ran
    • GTPase Ran
    • Guanosine triphosphatase Ran
    • LPS
    • OK/SW-cl.81
    • ran
    • RAN member RAS oncogene family
    • RAN_HUMAN
    • RanGTPase
    • Ras like protein TC4
    • Ras related nuclear protein
    • Ras-like protein TC4
    • Ras-related nuclear protein
    • RASL2 8
    • TC 4
    • TC4
    see all
  • Function

    GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • Tissue specificity

    Expressed in a variety of tissues.
  • Sequence similarities

    Belongs to the small GTPase superfamily. Ran family.
  • Post-translational
    modifications

    The N-terminus is blocked.
  • Cellular localization

    Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

References

ab90206 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab90206.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up