Recombinant Human Ras protein (ab61239)


  • Product name
    Recombinant Human Ras protein
  • Protein length
    Full length protein


  • Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
    • Tags
      GST tag N-Terminus

Associated products


Our Abpromise guarantee covers the use of ab61239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • C-BAS/HAS
    • c-H-ras
    • C-HA-RAS1
    • CTLO
    • GTPase HRas
    • GTPase KRas
    • GTPase NRas
    • H-Ras-1
    • H-RASIDX
    • Ha-Ras
    • HAMSV
    • HRAS
    • HRAS1
    • K RAS2A
    • K RAS2B
    • K RAS4A
    • K RAS4B
    • K-RAS
    • KRAS
    • KRAS1
    • KRAS2
    • N-RAS
    • N-terminally processed
    • NRAS
    • NRAS1
    • p21ras
    • RASH1
    • RASK2
    • Transforming protein p21
    • v Ha ras Harvey rat sarcoma viral oncogene homolog
    • v Ki ras2 Kirsten rat sarcoma viral oncogene homolog
    • v ras neuroblastoma RAS viral oncogene homolog
    see all
  • Function
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • Involvement in disease
    Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS) [MIM:218040]. A rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities.
    Defects in HRAS are the cause of congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040]. CMEMS is a variant of Costello syndrome.
    Defects in HRAS may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
    Note=Mutations which change positions 12, 13 or 61 activate the potential of HRAS to transform cultured cells and are implicated in a variety of human tumors.
    Defects in HRAS are a cause of susceptibility to bladder cancer (BLC) [MIM:109800]. A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
    Note=Defects in HRAS are the cause of oral squamous cell carcinoma (OSCC).
  • Sequence similarities
    Belongs to the small GTPase superfamily. Ras family.
  • Post-translational
    Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
    S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.
  • Cellular localization
    Cell membrane. Golgi apparatus membrane. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus.
  • Information by UniProt



ab61239 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Gracias por contactarnos.

La proteína tiene un tag unido a su posición N terminal correspondiente a GST.

Me gustaría informarte de que actualmente tenemos una promoción por la que al enviar cualquier anti...

Read More

Thank you for your enquiry. There is a N-terminal GST tag on the RAS Protein. If you have any additional questions, please feel free to contact me.


Sign up