Overview

  • Product name

    Recombinant Human RBM5 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDR YDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTI MLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHL QDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLK CFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTA LSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPP LKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQS GEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTA VTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVP GTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDG EKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMER
    • Molecular weight

      88 kDa including tags
    • Amino acids

      1 to 546

Associated products

Specifications

Our Abpromise guarantee covers the use of ab132608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • FLJ39876
    • G15
    • H37
    • LUCA 15
    • LUCA15
    • Protein G15
    • Putative tumor suppressor LUCA15
    • RBM 5
    • Rbm5
    • RBM5_HUMAN
    • Renal carcinoma antigen NY REN 9
    • Renal carcinoma antigen NY-REN-9
    • RMB 5
    • RMB5
    • RNA binding motif protein 5
    • RNA binding protein 5
    • RNA-binding motif protein 5
    • RNA-binding protein 5
    • Tumor suppressor LUCA15
    see all
  • Function

    Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
  • Tissue specificity

    Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
  • Sequence similarities

    Belongs to the RBM5/RBM10 family.
    Contains 1 C2H2-type zinc finger.
    Contains 1 G-patch domain.
    Contains 1 RanBP2-type zinc finger.
    Contains 2 RRM (RNA recognition motif) domains.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab132608 stained with Coomassie Blue.

References

ab132608 has not yet been referenced specifically in any publications.

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