Recombinant Human Renalase protein (denatured) (ab134535)
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- References
- Protocols
Description
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Product name
Recombinant Human Renalase protein (denatured)
See all Renalase proteins and peptides -
Purity
> 90 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHHSSGLVPRGSHMGSMALLRRQTSGPLYLAVWDKAEDSGGRM TTACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPI EGMVMKEGDCNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWE VSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISECQRQQLEAVSYSSR YALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLV IHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQV TNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI -
Predicted molecular weight
39 kDa including tags -
Amino acids
18 to 342 -
Tags
His tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab134535 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 12.01% Urea, 0.32% Tris HCl, 10% Glycerol
General Info
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Alternative names
- 6530404N21Rik
- AI452315
- AW060440
see all -
Function
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. -
Tissue specificity
Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. -
Sequence similarities
Belongs to the renalase family. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human Renalase protein (denatured) (ab134535)15% SDS-PAGE analysis of 3 µg ab134535.
Datasheets and documents
References
ab134535 has not yet been referenced specifically in any publications.
