Recombinant Human Renin Receptor protein (ab153053)

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Overview

Description

  • Nature

    Recombinant

  • Source

    Wheat germ
  • Amino Acid Sequence

    • Species

      Human

    • Sequence

      MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSM GFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLEN AVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVT LRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRH KHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADD MYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYN FEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD

    • Amino acids

      1 to 350

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

    Protein target previously labeled as POU3F2.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • APT6M8 9
    • APT6M8-9
    • ATP6AP2
    • ATP6IP2
    • ATP6M8-9
    • ATPase H(+)-transporting lysosomal accessory protein 2
    • ATPase H(+)-transporting lysosomal-interacting protein 2
    • ATPase H+ transporting lysosomal accessory protein 2
    • ATPase H+ transporting lysosomal interacting protein 2
    • ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9
    • ATPase membrane sector associated protein M8 9
    • ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9
    • CAPER
    • ELDF10
    • Embryonic liver differentiation factor 10
    • ER localized type I transmembrane adaptor
    • ER-localized type I transmembrane adaptor
    • HT028
    • M8 9
    • M8-9
    • MGC99577
    • MRXE
    • MSTP009
    • N14F
    • Renin receptor
    • Renin/prorenin receptor
    • RENR_HUMAN
    • V ATPase M8 9 subunit
    • V ATPase M8.9 subunit
    • V-ATPase M8.9 subunit
    • Vacuolar ATP synthase membrane sector associated protein M8 9
    • Vacuolar ATP synthase membrane sector-associated protein M8-9
    • vacuolar proton ATP synthase membrane sector associated protein M8 9
    • XMRE
    see all

  • Function

    Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).

  • Tissue specificity

    Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.

  • Involvement in disease

    Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE) [MIM:300423]. MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.

  • Post-translational
    modifications

    Phosphorylated.

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Renin Receptor protein (ab153053)
    SDS-PAGE - Recombinant Human Renin Receptor protein (ab153053)
    ab153053 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153053 has not yet been referenced specifically in any publications.

Publishing research using ab153053? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Evaluation of recombinant ATP6IP2 effect on CHO-M2 cell line viability

 Excellent
Abreviews
abreview image
Application
Other
The effect of recombinant protein on cell viability is assessed using MTS viability determination method on cultured CHO-M2 cells, incubated 42h in presence of different concentrations (45.5 – 22.7 – 11.4 – 5.7 – 2.8 – 1.4 nM) of rATP6IP2.

CONCLUSION
The viability is similar for the different concentration of rATP6IP2. It doesn’t affect cell viability.

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Submitted Aug 26 2016

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