Recombinant Human Renin Receptor protein (ab167955)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MKHHHHHHAS NEFSILKSPG SVVFRNGNWP IPGERIPDVA ALSMGFSVKE DLSWPGLAVG NLFHRPRATV MVMVKGVNKL ALPPGSVISY PLENAVPFSL DSVANSIHSL FSEETPVVLQ LAPSEERVYM VGKANSVFED LSVTLRQLRN RLFQENSVLS SLPLNSLSRN NEVDLLFLSE LQVLHDISSL LSRHKHLAKD HSPDLYSLEL AGLDEIGKRY GEDSEQFRDA SKILVDALQK FADDMYSLYG GNAVVELVTV KSFDTSLIRK TRTILEAKQA KNPASPYNLA YKYNFE
    • Molecular weight
      33 kDa including tags
    • Amino acids
      17 to 302
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    > 90 % Densitometry.
    ab167955 was purifed using Ni-NTA chromatography and filtered (0.4 µm).
  • Form
    Lyophilised
  • Additional notes

    Protein target previously labeled as POU3F2.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    pH: 7.50
    Constituents: 0.24% Tris, 0.29% Sodium chloride

  • Reconstitution
    Add 200 µl of deionized water to prepare a working stock solution of 0.5 mg/ml and let the lyophilized pellet dissolve completely. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage.

    Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

General Info

  • Alternative names
    • APT6M8 9
    • APT6M8-9
    • ATP6AP2
    • ATP6IP2
    • ATP6M8-9
    • ATPase H(+)-transporting lysosomal accessory protein 2
    • ATPase H(+)-transporting lysosomal-interacting protein 2
    • ATPase H+ transporting lysosomal accessory protein 2
    • ATPase H+ transporting lysosomal interacting protein 2
    • ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9
    • ATPase membrane sector associated protein M8 9
    • ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9
    • CAPER
    • ELDF10
    • Embryonic liver differentiation factor 10
    • ER localized type I transmembrane adaptor
    • ER-localized type I transmembrane adaptor
    • HT028
    • M8 9
    • M8-9
    • MGC99577
    • MRXE
    • MSTP009
    • N14F
    • Renin receptor
    • Renin/prorenin receptor
    • RENR_HUMAN
    • V ATPase M8 9 subunit
    • V ATPase M8.9 subunit
    • V-ATPase M8.9 subunit
    • Vacuolar ATP synthase membrane sector associated protein M8 9
    • Vacuolar ATP synthase membrane sector-associated protein M8-9
    • vacuolar proton ATP synthase membrane sector associated protein M8 9
    • XMRE
    see all
  • Function
    Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).
  • Tissue specificity
    Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.
  • Involvement in disease
    Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE) [MIM:300423]. MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • 14% SDS-PAGE analysis of ab167955
    Lane 1: MWt marker
    Lane 2: reduced and boiled sample, 2.5 μg
    Lane 3: non-reduced and non-boiled sample, 2.5 μg

References

ab167955 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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