Recombinant Human Retinoblastoma binding protein 6 (ab159317)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      SSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRE TDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAA VVQVGISRNQ
    • Amino acids
      1582 to 1691
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DKFZp686P0638
    • DKFZp761B2423
    • E3 ubiquitin-protein ligase RBBP6
    • MY038
    • P2P R
    • P2PR
    • p53 associated cellular protein of testis
    • p53-associated cellular protein of testis
    • p53-associated cellular protein, testis-derived
    • PACT
    • Proliferation potential related protein
    • Proliferation potential-related protein
    • Protein P2P R
    • Protein P2P-R
    • Protein P2PR
    • Protein RBQ 1
    • Protein RBQ1
    • RB binding protein 6, ubiquitin ligase
    • RB binding Q protein 1
    • RBBP 6
    • Rbbp6
    • RBBP6_HUMAN
    • RBQ 1
    • RBQ-1
    • RBQ1
    • Retinoblastoma binding protein 6 isoform 3
    • Retinoblastoma binding Q protein 1
    • Retinoblastoma-binding protein 6
    • Retinoblastoma-binding Q protein 1
    • SNAMA
    • SNAMA, Drosophila, homolog of
    see all
  • Function
    E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
  • Tissue specificity
    Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 CCHC-type zinc finger.
    Contains 1 DWNN domain.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6.
  • Cellular localization
    Nucleus > nucleolus. Chromosome. Cytoplasm > cytoskeleton > centrosome. Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
  • Information by UniProt

Images

  • ab159317 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159317 has not yet been referenced specifically in any publications.

Publishing research using ab159317? Please let us know so that we can cite the reference in this datasheet.

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