Recombinant Human Retinoblastoma binding protein 6 (ab159317)

Product name

Recombinant Human Retinoblastoma binding protein 6
See all Retinoblastoma binding protein 6 proteins and peptides
Protein length

Protein fragment

Nature

Recombinant
Source

Wheat germ
Amino Acid Sequence
- Species
  
  Human
- Sequence
  
  SSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRE TDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAA VVQVGISRNQ
- Amino acids
  
  1582 to 1691
- Tags
  
  proprietary tag N-Terminus

Our Abpromise guarantee covers the use of ab159317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Western blot

ELISA
Form

Liquid
Additional notes

Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...

Stability and Storage

Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl

Alternative names
- DKFZp686P0638
- DKFZp761B2423
- E3 ubiquitin-protein ligase RBBP6
- MY038
- P2P R
- P2PR
- p53 associated cellular protein of testis
- p53-associated cellular protein of testis
- p53-associated cellular protein, testis-derived
- PACT
- Proliferation potential related protein
- Proliferation potential-related protein
- Protein P2P R
- Protein P2P-R
- Protein P2PR
- Protein RBQ 1
- Protein RBQ1
- RB binding protein 6, ubiquitin ligase
- RB binding Q protein 1
- RBBP 6
- Rbbp6
- RBBP6_HUMAN
- RBQ 1
- RBQ-1
- RBQ1
- Retinoblastoma binding protein 6 isoform 3
- Retinoblastoma binding Q protein 1
- Retinoblastoma-binding protein 6
- Retinoblastoma-binding Q protein 1
- SNAMA
- SNAMA, Drosophila, homolog of
see all
Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Tissue specificity

Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
Pathway

Protein modification; protein ubiquitination.
Sequence similarities

Contains 1 CCHC-type zinc finger.
Contains 1 DWNN domain.
Contains 1 RING-type zinc finger.
Post-translational
modifications

Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6.
Cellular localization

Nucleus > nucleolus. Chromosome. Cytoplasm > cytoskeleton > centrosome. Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
Target information above from: UniProt accession Q7Z6E9 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human Retinoblastoma binding protein 6 (ab159317)

ab159317 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Datasheet

ab159317 has not yet been referenced specifically in any publications.

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Recombinant Human Retinoblastoma binding protein 6 (ab159317)

Overview

Description

Specifications

Preparation and Storage

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