Description

  • Product name

    Recombinant Human REXO1 protein
  • Purity

    > 90 % SDS-PAGE.
    ab177672 is purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIYAL DCEMSYTTYG LELTRVTVVD TDVHVVYDTF VKPDNEIVDY NTRFSGVTEA DLADTSVTLR DVQAVLLSMF SADTILIGHS LESDLLALKV IHSTVVDTSV LFPHRLGLPY KRSLRNLMAD YLRQIIQDNV DGHSSSEDAG ACMHLVIWKV REDAKTKR
    • Predicted molecular weight

      22 kDa including tags
    • Amino acids

      1060 to 1221
    • Tags

      His tag N-Terminus
    • Additional sequence information

      (NP_065746.3)

Specifications

Our Abpromise guarantee covers the use of ab177672 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names

    • EloA BP1
    • ELOABP1
    • Elongin A binding protein 1
    • KIAA1138
    • REX1, RNA exonuclease 1 homolog (S. cerevisiae)
    • RNA exonuclease 1 homolog
    • TCEB3BP1
    • Transcription elongation factor B polypeptide 3 binding protein 1
    see all
  • Relevance

    REXO1 or Elongin A-binding protein 1 (EloA-BP1) is an exonuclease domain-containing protein that can bind to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although REXO1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo.
  • Cellular localization

    Nuclear

Images

  • 15% SDS-PAGE analysis of ab177672 (3μg).

References

ab177672 has not yet been referenced specifically in any publications.

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