The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
A1 40 kDa subunit
Activator 1 40 kDa subunit
Activator 1 subunit 2
Replication factor C (activator 1) 2
Replication factor C (activator 1) 2 40kDa
Replication factor C 2
Replication factor C 40 kDa subunit
Replication factor C subunit 2
RF C 40 kDa subunit
RF-C 40 kDa subunit
RFC 40 kDa subunit
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP.
Involvement in disease
Note=RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.