Recombinant Human RFXANK protein (ab167884)
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Overview
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Product nameRecombinant Human RFXANK protein
See all RFXANK proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMGSSHHHHHH SSGLVPRGSH MGSMELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE
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Molecular weight28 kDa including tags
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Amino acids1 to 237
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TagsHis tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab167884 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Mass Spectrometry
SDS-PAGE
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Mass spectrometryMALDI-TOF
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Purity> 85 % SDS-PAGE.
ab167884 is purified using conventional chromatography techniques. -
FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.32% Tris HCl, 20% Glycerol, 0.88% Sodium chloride
General Info
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Alternative names
- ANKRA1
- Ankyrin repeat containing regulatory factor X associated protein
- Ankyrin repeat family A protein 1
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FunctionActivates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
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Tissue specificityUbiquitous.
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Involvement in diseaseDefects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
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Sequence similaritiesContains 5 ANK repeats.
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DomainThe third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
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Cellular localizationNucleus.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human RFXANK protein (ab167884)15% SDS-PAGE analysis of ab167884 (3µg).
Datasheets and documents
References
ab167884 has not yet been referenced specifically in any publications.
