Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE
    • Molecular weight
      28 kDa including tags
    • Amino acids
      1 to 237
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    ab167884 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • ANKRA1
    • Ankyrin repeat containing regulatory factor X associated protein
    • Ankyrin repeat family A protein 1
    • BLS
    • DNA-binding protein RFXANK
    • F14150_1
    • MGC138628
    • Regulatory factor X associated ankyrin containing protein
    • Regulatory factor X subunit B
    • Regulatory factor X, ankyrin repeat containing
    • Regulatory factor X-associated ankyrin-containing protein
    • RFX Bdelta4
    • RFX-B
    • RFXANK
    • RFXB
    • RFXB delta 4
    • RFXK_HUMAN
    see all
  • Function
    Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
  • Sequence similarities
    Contains 5 ANK repeats.
  • Domain
    The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab167884 (3µg).

References

ab167884 has not yet been referenced specifically in any publications.

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