Overview

  • Product name
    Recombinant Human RGS19 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P49795
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMPTPHEAEKQITGPEEADRPPSMSSHDTAS PAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPS PEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEA NQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDA QLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
    • Molecular weight
      27 kDa including tags
    • Amino acids
      1 to 217
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab101949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 90 % SDS-PAGE.
    ab101949 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, PBS, pH 7.4

General Info

  • Alternative names
    • G alpha interacting protein
    • G protein signalling regulator 19
    • G protein, alpha-interacting protein
    • G-alpha-interacting protein
    • GAIP
    • GNAI3IP
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
    • Regulator of G protein signalling 19
    • Regulator of G-protein signaling 19
    • RGS19
    • RGS19_HUMAN
    • RGSGAIP
    see all
  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • Tissue specificity
    Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • Sequence similarities
    Contains 1 RGS domain.
  • Post-translational
    modifications
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    Phosphorylated, mainly on serine residues.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human RGS19 protein (ab101949)
    SDS-PAGE - Recombinant Human RGS19 protein (ab101949)
    15% SDS-PAGE analysis of 3µg ab101949.

References

ab101949 has not yet been referenced specifically in any publications.

Publishing research using ab101949? Please let us know so that we can cite the reference in this datasheet.

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