Recombinant Human RGS19 protein (ab101949)

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SDS-PAGE - Recombinant Human RGS19 protein (ab101949)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human RGS19 protein

    • Purity

      > 90 % SDS-PAGE.
      ab101949 is purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      P49795

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMPTPHEAEKQITGPEEADRPPSMSSHDTAS PAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPS PEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEA NQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDA QLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA

      • Predicted molecular weight

        27 kDa including tags

      • Amino acids

        1 to 217

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab101949 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

      pH: 7.40
      Constituents: PBS, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • G alpha interacting protein
      • G protein signalling regulator 19
      • G protein, alpha-interacting protein
      • G-alpha-interacting protein
      • GAIP
      • GNAI3IP
      • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
      • Regulator of G protein signalling 19
      • Regulator of G-protein signaling 19
      • RGS19
      • RGS19_HUMAN
      • RGSGAIP
      see all

    • Function

      Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

    • Tissue specificity

      Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

    • Sequence similarities

      Contains 1 RGS domain.

    • Post-translational
      modifications

      Fatty acylated. Heavily palmitoylated in the cysteine string motif.
      Phosphorylated, mainly on serine residues.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human RGS19 protein (ab101949)
      SDS-PAGE - Recombinant Human RGS19 protein (ab101949)
      15% SDS-PAGE analysis of 3µg ab101949.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab101949? Please let us know so that we can cite the reference in this datasheet.

    ab101949 has not yet been referenced specifically in any publications.

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