Recombinant Human RGS19 protein (ab101949)

Our Abpromise guarantee covers the use of ab101949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

SDS-PAGE

Mass Spectrometry
Mass spectrometry

MALDI-TOF
Purity

> 90 % SDS-PAGE.
ab101949 is purified using conventional chromatography techniques.
Form

Liquid
Concentration information loading...

Alternative names
- G alpha interacting protein
- G protein signalling regulator 19
- G protein, alpha-interacting protein
- G-alpha-interacting protein
- GAIP
- GNAI3IP
- Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
- Regulator of G protein signalling 19
- Regulator of G-protein signaling 19
- RGS19
- RGS19_HUMAN
- RGSGAIP
see all
Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Tissue specificity

Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Sequence similarities

Contains 1 RGS domain.
Post-translational
modifications

Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
Cellular localization

Membrane.
Target information above from: UniProt accession P49795 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human RGS19 protein (ab101949)

15% SDS-PAGE analysis of 3µg ab101949.

ab101949 has not yet been referenced specifically in any publications.

Publishing research using ab101949? Please let us know so that we can cite the reference in this datasheet.

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