Description

  • Product name

    Recombinant Human RNF135 protein
  • Expression system

    Wheat germ
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHCLEALWG ARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAH CPCPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVR SLQNQRPLSESGPDNELSILGKENSWKPRLPPHAHCLTRATLHSGELLGL LSGPSIQPLT
    • Amino acids

      1 to 210
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • E3 ubiquitin-protein ligase RNF135
    • L13
    • MGC13061
    • MMFD
    • REUL
    • RIG-I E3 ubiquitin ligase
    • RING finger protein 135
    • Riplet
    • RN135_HUMAN
    • Rnf135
    see all
  • Function

    Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.
  • Tissue specificity

    Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.
  • Pathway

    Protein modification; protein ubiquitination.
  • Involvement in disease

    Defects in RNF135 are the cause of macrocephaly macrosomia facial dysmorphism syndrome (MMFD) [MIM:614192]. MMFD is an autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction.
  • Sequence similarities

    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • ab164552 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164552 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab164552.
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