Product nameRecombinant Human RNPS1 protein
See all RNPS1 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMASMTGGQQMGRGEFMDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRS DEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRR RSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYG KIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITA TAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRR RSRSPGRRRHRSRSSSNSSR
Molecular weight36 kDa
Amino acids1 to 305
TagsT7 tag N-Terminus
- Anti-T7 tag® antibody (DyLight® 550) (ab117595)
- Anti-T7 tag® antibody (Agarose) (ab1230)
- Anti-T7 tag® antibody (HRP) (ab19291)
- Anti-T7 tag® antibody (HRP) (ab21477)
- Anti-T7 tag® antibody (Phycoerythrin) (ab72563)
- Anti-T7 tag® antibody (SureLight® Allophycocyanin) (ab72565)
- Anti-RNPS1 antibody (ab79233)
- Anti-T7 tag® antibody (ab9115)
- Anti-T7 tag® antibody (ab9138)
- Anti-T7 tag® antibody (ab97964)
Our Abpromise guarantee covers the use of ab169913 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity>90% by SDS-PAGE.
ab169913 was expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituent: 0.32% Tris HCl
Note: Contains NaCl, KCl, EDTA, arginine, DTT and glycerol.
- RNA binding protein S1 serine rich domain
FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
Sequence similaritiesBelongs to the splicing factor SR family.
Contains 1 RRM (RNA recognition motif) domain.
modificationsPhosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
Cellular localizationNucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
- Information by UniProt
ab169913 has not yet been referenced specifically in any publications.