Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GSSHHHHHH SSGLVPRGSH MGSMAESLRS PRRSLYKLVG SPPWKEAFRQ RCLERMRNSR DRLLNRYRQA GSSGPGNSQN SFLVQEVMEE EWNALQSVEN CPEDLAQLEE LIDMAVLEEI QQELINQGL
    • Molecular weight
      15 kDa including tags
    • Amino acids
      1 to 106
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab168078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 40% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names
    • 2400006N03Rik
    • DN-393H17.1
    • FLJ25625
    • FLJ30490
    • FLJ42429
    • HRIP
    • MGC4189
    • Nuclear transporter
    • RAP interaction protein
    • RIP
    • RIP_HUMAN
    • RP23 83I13.5
    • RPA interacting protein
    • RPA-interacting protein
    • Rpain
    see all
  • Function
    Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
  • Tissue specificity
    Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
  • Sequence similarities
    Contains 1 RIP-type zinc finger.
  • Post-translational
    modifications
    Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.
  • Cellular localization
    Cytoplasm. Nucleus and Nucleus > PML body.
  • Information by UniProt

Images

  • 3 µg ab168078 on 15% SDS-PAGE

References

ab168078 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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