Recombinant human RSPO3 protein (ab204625)

Submit a review Submit a question

Description

  • Product name

    Recombinant human RSPO3 protein
    See all RSPO3 proteins and peptides

  • Biological activity

    RSPO3 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.

  • Purity

    > 95 % SDS-PAGE.
    >95% pure by HPLC.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    CHO cells

  • Accession

    Q9BXY4

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPS GYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQH PSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAI PDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH

    • Predicted molecular weight

      27 kDa

    • Amino acids

      33 to 272

    • Additional sequence information

      NP_116173.2.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

    Functional Studies

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • CRISTIN1
    • hPWTSR
    • hRspo3
    • Protein with TSP type-1 repeat
    • PWTSR
    • R-spondin 3 homolog
    • R-spondin-3
    • R-spondin-3 [Precursor]
    • Roof plate specific spondin-3
    • Roof plate-specific spondin-3
    • RSPO3
    • RSPO3_HUMAN
    • Thrombospondin type I domain containing 2
    • Thrombospondin type-1 domain-containing protein 2
    • THSD2
    see all

  • Function

    Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

  • Tissue specificity

    Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node.

  • Sequence similarities

    Belongs to the R-spondin family.
    Contains 2 FU (furin-like) repeats.
    Contains 1 TSP type-1 domain.

  • Domain

    The FU repeats are required for activation and stabilization of beta-catenin.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab204625 has not yet been referenced specifically in any publications.

Publishing research using ab204625? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

There are currently no Customer reviews or Questions for ab204625.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com