Description

  • Product name

    Recombinant Human SAE2 / UBA2 protein
    See all SAE2 / UBA2 proteins and peptides
  • Purity

    > 85 % Densitometry.

  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLD TIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD YNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTT IKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEE DADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYD PVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPS AMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVL EGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEV TVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEA NNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA PEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
    • Predicted molecular weight

      115 kDa including tags
    • Amino acids

      1 to 640
    • Tags

      GST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab140416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • Anthracycline associated resistance ARX
    • Anthracycline-associated resistance ARX
    • ARX
    • FLJ13058
    • HRIHFB2115
    • SAE 2
    • SAE2
    • SAE2_HUMAN
    • SUMO 1 activating enzyme subunit 2
    • SUMO activating enzyme subunit 2
    • SUMO-activating enzyme subunit 2
    • UBA2
    • UBA2 ubiquitin activating enzyme E1 homolog
    • Ubiquitin like 1 activating enzyme E1B
    • Ubiquitin like modifier activating enzyme 2
    • Ubiquitin-like 1-activating enzyme E1B
    • UBLE1B
    see all
  • Function

    The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • Pathway

    Protein modification; protein sumoylation.
  • Sequence similarities

    Belongs to the ubiquitin-activating E1 family.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab140416.

References

ab140416 has not yet been referenced specifically in any publications.

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