Description

  • Product name

    Recombinant Human SARA protein
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      30 kDa
    • Amino acids

      1013 to 1280
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • CG15667
    • hSARA
    • LD33044p
    • Madh-interacting protein
    • MADHIP
    • Mothers against decapentaplegic homolog-interacting protein
    • Novel serine protease
    • NSP
    • Receptor activation anchor
    • SAR1
    • SARA
    • SARA1
    • Smad anchor for receptor activation
    • SMADIP
    • ZFYV9_HUMAN
    • ZFYVE9
    • Zinc finger FYVE domain-containing protein 9
    see all
  • Function

    Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
  • Tissue specificity

    Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
  • Sequence similarities

    Contains 1 FYVE-type zinc finger.
  • Domain

    The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3.
    The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.
  • Cellular localization

    Cytoplasm. Early endosome membrane.
  • Information by UniProt

References

ab127442 has not yet been referenced specifically in any publications.

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