Recombinant Human SCO2 protein (ab103492)

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SDS-PAGE - Recombinant Human SCO2 protein (ab103492)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human SCO2 protein

    • Purity

      > 90 % SDS-PAGE.
      ab103492 was purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      O43819

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMGPAETGGQGQPQGPGLRTRLLITGLFGAG LGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFR GQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPE RDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDY IVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS

      • Predicted molecular weight

        27 kDa including tags

      • Amino acids

        42 to 266

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab103492 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.0308% DTT, 0.316% Tris HCl, 30% Glycerol (glycerin, glycerine), 1.16% Sodium chloride

    General Info

    • Alternative names

      • Cytochrome oxidase deficient homolog 2
      • MGC125823
      • MGC125825
      • OTTHUMP00000196774
      • OTTHUMP00000196775
      • Protein SCO2 homolog, mitochondrial
      • SCO (cytochrome oxidase deficient, yeast) homolog 2
      • SCO 1L
      • SCO 2
      • SCO cytochrome oxidase deficient homolog 2
      • SCO cytochrome oxidase deficient homolog 2 (yeast)
      • SCO1L
      • SCO2
      • SCO2_HUMAN
      • Synthesis of cytochrome c oxidase 2
      see all

    • Function

      Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).

    • Tissue specificity

      Ubiquitous.

    • Involvement in disease

      Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.

    • Sequence similarities

      Belongs to the SCO1/2 family.
      Contains 1 thioredoxin domain.

    • Cellular localization

      Mitochondrion.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human SCO2 protein (ab103492)
      SDS-PAGE - Recombinant Human SCO2 protein (ab103492)
      15% SDS-PAGE analysis of 3µg ab103492.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab103492? Please let us know so that we can cite the reference in this datasheet.

    ab103492 has not yet been referenced specifically in any publications.

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