Recombinant Human SCO2 protein (ab103492)

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Description

  • Product name

    Recombinant Human SCO2 protein

  • Purity

    > 90 % SDS-PAGE.
    ab103492 was purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    O43819

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGPAETGGQGQPQGPGLRTRLLITGLFGAG LGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFR GQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPE RDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDY IVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS

    • Predicted molecular weight

      27 kDa including tags

    • Amino acids

      42 to 266

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab103492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.0308% DTT, 0.316% Tris HCl, 30% Glycerol, 1.16% Sodium chloride

General Info

  • Alternative names

    • Cytochrome oxidase deficient homolog 2
    • MGC125823
    • MGC125825
    • OTTHUMP00000196774
    • OTTHUMP00000196775
    • Protein SCO2 homolog, mitochondrial
    • SCO (cytochrome oxidase deficient, yeast) homolog 2
    • SCO 1L
    • SCO 2
    • SCO cytochrome oxidase deficient homolog 2
    • SCO cytochrome oxidase deficient homolog 2 (yeast)
    • SCO1L
    • SCO2
    • SCO2_HUMAN
    • Synthesis of cytochrome c oxidase 2
    see all

  • Function

    Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).

  • Tissue specificity

    Ubiquitous.

  • Involvement in disease

    Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.

  • Sequence similarities

    Belongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.

  • Cellular localization

    Mitochondrion.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human SCO2 protein (ab103492)
    SDS-PAGE - Recombinant Human SCO2 protein (ab103492)
    15% SDS-PAGE analysis of 3µg ab103492.

References

ab103492 has not yet been referenced specifically in any publications.

Publishing research using ab103492? Please let us know so that we can cite the reference in this datasheet.

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