Description

  • Product name

    Recombinant Human Scramblase 1 protein
  • Purity

    > 90 % SDS-PAGE.
    ab136366 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVK
    • Predicted molecular weight

      34 kDa including tags
    • Amino acids

      1 to 288
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab136366 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • Ca(2+) dependent phospholipid scramblase 1
    • Ca(2+)-dependent phospholipid scramblase 1
    • Erythrocyte phospholipid scramblase
    • MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of
    • MmTRA1a
    • MmTRA1b
    • Nor1
    • Phospholipid scramblase 1
    • PL scramblase 1
    • PLS1_HUMAN
    • PLSCR 1
    • Plscr1
    • Scramblase1
    • Tra1
    • Tra1a
    • Tra1b
    • Transplantability-associated protein 1
    • Tras1
    • Tras2
    see all
  • Function

    May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
    May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
  • Tissue specificity

    Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
  • Sequence similarities

    Belongs to the phospholipid scramblase family.
  • Post-translational
    modifications

    Known to be palmitoylated at one, yet undefined, site.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab136366 (3 µg)

References

ab136366 has not yet been referenced specifically in any publications.

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