Suppressor of defective silencing 3 homolog (S cerevisiae)
Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae)
Suppressor of defective silencing 3 protein homolog
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Expressed in various cancer cell ines.
Belongs to the SDS3 family.
The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.