This product is an active protein and may elicit a biological response in vivo, handle with caution.
Sentrin specific protease 1
Sentrin-specific protease 1
Sentrin/SUMO specific protease
Sentrin/SUMO specific protease 1
Sentrin/SUMO specific protease SENP 1
Sentrin/SUMO specific protease SENP1
Sentrin/SUMO-specific protease SENP1
SUMO1/sentrin specific peptidase 1
SUMO1/sentrin specific protease 1
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Belongs to the peptidase C48 family.
Nucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.