Description

  • Product name

    Recombinant Human SEPSECS protein
  • Purity

    > 90 % SDS-PAGE.
    ab102021 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRPKAKYIIWPRI DQKSCFKSMI TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV ICANYDIPHIVNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ GSMLFTRQV SGARVVPLGS MQTVSGYTFR GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD IEEMALKLDN VLLDTYQDAS S
    • Predicted molecular weight

      58 kDa including tags
    • Amino acids

      1 to 501
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab102021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Additional notes

    Previously labelled as Soluble Liver/Pancreas Antigen.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • DKFZp434B1417
    • Liver pancreas antigen
    • Liver-pancreas antigen
    • LP
    • MGC161491
    • O phosphoseryl tRNA(Sec) selenium transferase
    • O-phosphoseryl-tRNA(Sec) selenium transferase
    • Sec synthase
    • Selenocysteine synthase
    • Selenocysteinyl tRNA(Sec) synthase
    • Selenocysteinyl-tRNA(Sec) synthase
    • Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
    • Sep tRNA:Sec tRNA synthase
    • Sep-tRNA:Sec-tRNA synthase
    • SepSecS
    • SLA
    • SLA p35
    • SLA-p35
    • SLA/LP
    • SLA/LP autoantigen
    • Soluble liver antigen
    • Soluble liver antigen/liver pancreas antigen
    • Soluble Liver/Pancreas Antigen
    • SPCS_HUMAN
    • tRNA(Ser/Sec) associated antigenic protein
    • tRNA(Ser/Sec)-associated antigenic protein
    • TRNP48
    • UGA suppressor tRNA associated protein
    • UGA suppressor tRNA-associated protein
    see all
  • Function

    Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
  • Tissue specificity

    Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
  • Pathway

    Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.
  • Involvement in disease

    Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D) [MIM:613811]. PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures.
  • Sequence similarities

    Belongs to the SepSecS family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3 µg ab102021.

References

ab102021 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab102021.
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