Recombinant Human Serine Palmitoyltransferase protein (ab152996)
- Datasheet
- References
- Protocols
Overview
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Product name
Recombinant Human Serine Palmitoyltransferase protein
See all Serine Palmitoyltransferase proteins and peptides -
Protein length
Full length protein
Description
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Nature
Recombinant -
Source
Wheat germ -
Amino Acid Sequence
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Species
Human -
Sequence
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ NGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCH HATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIME RQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYG AGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALV GKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIG ALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRT HSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFR RRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPA TPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDR PFDETTYEETED -
Amino acids
1 to 562 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab152996 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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Form
Liquid -
Additional notes
Protein concentration is above or equal to 0.05 mg/ml. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- KIAA0526
- LCB 2
- LCB2
see all -
Function
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate. -
Tissue specificity
Widely expressed. -
Pathway
Lipid metabolism; sphingolipid metabolism. -
Involvement in disease
Defects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640]. It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness. -
Sequence similarities
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human Serine Palmitoyltransferase protein (ab152996)ab152996 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab152996 has not yet been referenced specifically in any publications.
