Recombinant Human SerpinB6/CAP protein (ab127101)
- Datasheet
- References
- Protocols
Description
-
Product name
Recombinant Human SerpinB6/CAP protein
See all SerpinB6/CAP proteins and peptides -
Expression system
Escherichia coli -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Predicted molecular weight
24 kDa -
Amino acids
161 to 364 -
Tags
His-DHFR tag N-Terminus
-
Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab127101 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
-
Form
Lyophilised -
Additional notes
Product previously known as Recombinant Human SerpinB6/CAP protein.
-
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
-
ReconstitutionReconstitute with water to desired concentration
General Info
-
Alternative names
- CAP
- Cytoplasmic antiproteinase
- Peptidase inhibitor 6
see all -
Function
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. -
Tissue specificity
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. -
Involvement in disease
Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. -
Sequence similarities
Belongs to the serpin family. Ov-serpin subfamily. -
Cellular localization
Cytoplasm. - Information by UniProt
Datasheets and documents
References
ab127101 has not yet been referenced specifically in any publications.
