Description

  • Product name

    Recombinant Human SGF29 protein
  • Purity

    > 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV VSYSHATNKY EVDDIDEEGK ERHTLSRRRV IPLPQWKANP ETDPEALFQK EQLVLALYPQ TTCFYRALIH APPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK
    • Predicted molecular weight

      35 kDa including tags
    • Amino acids

      1 to 293
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • CCDC101
    • Coiled coil domain containing 101
    • Coiled coil domain containing protein 101
    • Coiled-coil domain-containing protein 101
    • FLJ32446
    • OTTMUSP00000030606
    • SAGA associated factor 29 homolog
    • SAGA-associated factor 29 homolog
    • SGF29_HUMAN
    • STAF36
    see all
  • Function

    Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preferrence for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.
  • Sequence similarities

    Belongs to the SGF29 family.
    Contains 1 SGF29 C-terminal domain.
  • Domain

    The SGF29 tudor-like domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS PAGE (3 µg loaded)

References

This product has been referenced in:

  • Beyrath J  et al. KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery. Sci Rep 8:6577 (2018). Read more (PubMed: 29700325) »
See 1 Publication for this product

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