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    recombinant-human-sh2b1psm-protein-ab161849.pdf

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Signal Transduction Adapters Cytoplasmic
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Recombinant Human SH2B1/PSM protein (ab161849)

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SDS-PAGE - Recombinant Human SH2B1/PSM protein (ab161849)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human SH2B1/PSM protein
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR SEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFV VKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPG TSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDR PSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYP PLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLALTGG TGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQ SIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCE GDGCHPDASCTLMPFGASDCVTDHLP
      • Amino acids

        1 to 426
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab161849 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

      This product was previously labelled as SH2B1.

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • DKFZp547G1110
      • FLJ30542
      • KIAA1299
      • PH and SH2 domain-containing signaling mediator
      • Pro-rich
      • Pro-rich, PH and SH2 domain-containing signaling mediator
      • PSM
      • SH2 B
      • SH2 domain-containing protein 1B
      • SH2 domain-containing putative adapter SH2-B
      • SH2-B signaling protein
      • SH2B
      • SH2B adapter protein 1
      • SH2B adaptor protein 1
      • Sh2b1
      • SH2B1 protein
      • SH2B1_HUMAN
      see all
    • Function

      Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis.
    • Tissue specificity

      Widely expressed with highest levels in skeletal muscle and ovary.
    • Sequence similarities

      Belongs to the SH2B adapter family.
      Contains 1 PH domain.
      Contains 1 SH2 domain.
    • Post-translational
      modifications

      Phosphorylated on tyrosine residues in response to receptor kinase stimulation. Phosphorylated by RET.
    • Cellular localization

      Cytoplasm. Membrane. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Target information above from: UniProt accession Q9NRF2 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human SH2B1/PSM protein (ab161849)
      SDS-PAGE - Recombinant Human SH2B1/PSM protein (ab161849)
      ab161849 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab161849? Please let us know so that we can cite the reference in this datasheet.

    ab161849 has not yet been referenced specifically in any publications.

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