Recombinant Human SH2D1A/SAP protein (BSA and azide free) (ab173077)

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Description

  • Product name

    Recombinant Human SH2D1A/SAP protein (BSA and azide free)
    See all SH2D1A/SAP proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    O60880

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMDAVAVYHGKISRETGEKLLLATGLDGSYL LRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKI KNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP

    • Predicted molecular weight

      16 kDa including tags

    • Amino acids

      1 to 128

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab173077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.24% Tris, 0.88% Sodium chloride, 10% Glycerol

    Supplied as a 0.2 µM filtered solution.

General Info

  • Alternative names

    • DSHP
    • Duncan disease SH2 protein
    • Duncan disease SH2-protein
    • EBVS
    • IMD5
    • LYP
    • MTCP1
    • SAP
    • SAP/SH2D1A
    • SH2 domain containing 1A
    • SH2 domain protein 1A
    • SH2 domain-containing protein 1A
    • SH21A_HUMAN
    • SH2D1A
    • Signaling lymphocyte activation molecule associated protein
    • Signaling lymphocytic activation molecule-associated protein
    • SLAM associated protein
    • SLAM associated protein/SH2 domain protein 1A
    • SLAM-associated protein
    • T cell signal transduction molecule SAP
    • T-cell signal transduction molecule SAP
    • XLP
    • XLPD
    see all

  • Function

    Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

  • Tissue specificity

    Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.

  • Involvement in disease

    Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.

  • Sequence similarities

    Contains 1 SH2 domain.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

References

ab173077 has not yet been referenced specifically in any publications.

Publishing research using ab173077? Please let us know so that we can cite the reference in this datasheet.

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