The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
c Cbl interacting protein
Cbl interacting protein
Cbl interacting protein of 85 kDa
Cbl-interacting protein of 85 kDa
CD2 binding protein 3
CD2-binding protein 3
Human Src family kinase binding protein 1
Human Src family kinase-binding protein 1
Migration inducing gene 18
Migration inducing gene 18 protein
SH3 domain kinase binding protein 1
SH3 domain-containing kinase-binding protein 1
Src family kinase binding protein 1
src related kinase binding protein 1
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
Ubiquitously expressed. Also expressed in some cancer cell lines.
Contains 3 SH3 domains.
The SH3 domains mediate interaction with SHKBP1.
Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
Cytoplasm > cytoskeleton. Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome. Cell junction > focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes.