The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Rai like protein
SH2 domain protein C4
SHC (Src homology 2 domain containing) family member 4
SHC adaptor protein 4
SHC family member 4
SHC transforming protein 4
SHC transforming protein D
SHC-transforming protein 4
SHC-transforming protein D
Src homology 2 domain containing family member 4
Src homology 2 domain containing transforming protein C4
Src homology 2 domain-containing-transforming protein C4
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
Contains 1 PID domain. Contains 1 SH2 domain.
Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
Cell junction > synapse > postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction.