Description

  • Product name

    Recombinant Human SIGIRR protein
  • Purity

    > 90 % SDS-PAGE.
    ab108572 is 0.2µm filtered
  • Endotoxin level

    < 0.100 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      50 kDa including tags
    • Amino acids

      1 to 118
    • Additional sequence information

      Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

Specifications

Our Abpromise guarantee covers the use of ab108572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Working aliquots are stable for up to 3 months when stored at -20°C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: PBS

General Info

  • Alternative names

    • Ig IL1 related receptor
    • MGC110992
    • SIGIR_HUMAN
    • SIGIRR
    • Single Ig IL 1 related receptor
    • Single Ig IL-1-related receptor
    • Single Ig IL-1R-related molecule
    • Single Ig IL1R Related Molecule
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain
    • Single immunoglobulin and toll interleukin 1 receptor domain
    • Single immunoglobulin domain containing IL1R related protein
    • Single immunoglobulin domain IL1R1 related
    • Single immunoglobulin domain-containing IL1R-related protein
    • TIR 8
    • TIR8
    • Toll/interleukin 1 receptor 8
    • Toll/interleukin-1 receptor 8
    see all
  • Function

    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Tissue specificity

    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • Sequence similarities

    Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab108572 has not yet been referenced specifically in any publications.

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