Recombinant Human SIGIRR protein (ab108572)

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Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
      Q6IA17
    • Species
      Human
    • Molecular weight
      50 kDa including tags
    • Amino acids
      1 to 118

Specifications

Our Abpromise guarantee covers the use of ab108572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 90 % SDS-PAGE.
    ab108572 is 0.2µm filtered
  • Form
    Liquid
  • Additional notes
    Working aliquots are stable for up to 3 months when stored at -20°C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • Ig IL1 related receptor
    • MGC110992
    • SIGIR_HUMAN
    • SIGIRR
    • Single Ig IL 1 related receptor
    • Single Ig IL-1-related receptor
    • Single Ig IL-1R-related molecule
    • Single Ig IL1R Related Molecule
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain
    • Single immunoglobulin and toll interleukin 1 receptor domain
    • Single immunoglobulin domain containing IL1R related protein
    • Single immunoglobulin domain IL1R1 related
    • Single immunoglobulin domain-containing IL1R-related protein
    • TIR 8
    • TIR8
    • Toll/interleukin 1 receptor 8
    • Toll/interleukin-1 receptor 8
    see all
  • Function
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Tissue specificity
    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • Sequence similarities
    Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab108572 has not yet been referenced specifically in any publications.

Publishing research using ab108572? Please let us know so that we can cite the reference in this datasheet.

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