Recombinant Human SIGIRR protein (ab108572)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human SIGIRR protein -
Purity
> 90 % SDS-PAGE.
ab108572 is 0.2µm filtered -
Endotoxin level
< 0.100 Eu/µg -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Predicted molecular weight
50 kDa including tags -
Amino acids
1 to 118 -
Additional sequence information
Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.
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Specifications
Our Abpromise guarantee covers the use of ab108572 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Working aliquots are stable for up to 3 months when stored at -20°C. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituent: PBS
General Info
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Alternative names
- Ig IL1 related receptor
- MGC110992
- SIGIR_HUMAN
see all -
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. -
Tissue specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
Datasheets and documents
References
ab108572 has not yet been referenced specifically in any publications.
