Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      RRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEE QKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKT
    • Amino acids

      465 to 549
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • CD170
    • CD170 antigen
    • CD33 antigen-like 2
    • CD33L2
    • mSiglec-F
    • OB-binding protein 2
    • OB-BP2
    • OBBP2
    • Obesity-binding protein 2
    • Sialic acid binding Ig-like lectin 5
    • Sialic acid binding immunoglobulin-like lectin 5
    • Sialic acid-binding Ig-like lectin 5
    • Sialic acid-binding Ig-like lectin F
    • SIGL5_HUMAN
    • Siglec-5
    • Siglec-F variant
    • Siglec5
    • Siglecf
    see all
  • Function

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificity

    Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • ab160181 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160181 has not yet been referenced specifically in any publications.

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