Recombinant Human SLAM / CD150 protein (denatured) (ab139259)
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Overview
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Product nameRecombinant Human SLAM / CD150 protein (denatured)
See all SLAM / CD150 proteins and peptides -
Protein lengthProtein fragment
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DescriptionRecombinant Human SLAM / CD150 protein
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMGSSHHHHHHSSGLVPRGSHMGSASYGTGGRMMNCPKILRQLGSKVLLPL TYERINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYK FYLENLTLGIRESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIK VLNKTQENGTCTLILGCTVEKGDHVAYSWSEKAGTHPLNPANSSHLLSLT LGPQHADNIYICTVSNPISNNSQTFSPWPGCRTDPSETKP
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Molecular weight27 kDa including tags
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Amino acids21 to 237
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TagsHis tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab139259 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Purity> 85 % SDS-PAGE.
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FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol
General Info
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Alternative names
- 4933415F16
- AA177906
- CD 150
see all -
FunctionHigh-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
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Tissue specificityConstitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
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Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
DomainThe most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
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Post-translational
modificationsPhosphorylated by FYN. -
Cellular localizationCell membrane. Present on the surface of B-cells and T-cells.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)15% SDS-PAGE analysis of 3 µg ab139259.
Datasheets and documents
References
ab139259 has not yet been referenced specifically in any publications.
