Recombinant Human SLAM / CD150 protein (denatured) (ab139259)

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Description

  • Product name

    Recombinant Human SLAM / CD150 protein (denatured)
    See all SLAM / CD150 proteins and peptides

  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    Q13291

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGSASYGTGGRMMNCPKILRQLGSKVLLPL TYERINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYK FYLENLTLGIRESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIK VLNKTQENGTCTLILGCTVEKGDHVAYSWSEKAGTHPLNPANSSHLLSLT LGPQHADNIYICTVSNPISNNSQTFSPWPGCRTDPSETKP

    • Predicted molecular weight

      27 kDa including tags

    • Amino acids

      21 to 237

    • Tags

      His tag N-Terminus

  • Description

    Recombinant Human SLAM / CD150 protein

Specifications

Our Abpromise guarantee covers the use of ab139259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • 4933415F16
    • AA177906
    • CD 150
    • CD150
    • CD150 antigen
    • CDw150
    • Estm51
    • Ipo 3
    • IPO-3
    • Ipo3
    • MGC151472
    • MGC151476
    • OTTHUMP00000025670
    • OTTHUMP00000060252
    • RGD1560634
    • Signaling lymphocytic activation molecule
    • Signaling lymphocytic activation molecule family member 1
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_a
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_b
    • Signaling lymphocytic activation molecule precursor
    • Slaf1
    • SLAF1_HUMAN
    • SLAM family, member 1
    • Slamf 1
    • SLAMF1
    • SLAMF1 protein
    see all

  • Function

    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

  • Tissue specificity

    Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Domain

    The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.

  • Post-translational
    modifications

    Phosphorylated by FYN.

  • Cellular localization

    Cell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)
    SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)
    15% SDS-PAGE analysis of 3 µg ab139259.

References

ab139259 has not yet been referenced specifically in any publications.

Publishing research using ab139259? Please let us know so that we can cite the reference in this datasheet.

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