Recombinant Human SLAM / CD150 protein (denatured) (ab139259)

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SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 85% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Human SLAM / CD150 protein (denatured)
      See all SLAM / CD150 proteins and peptides

    • Purity

      > 85 % SDS-PAGE.

    • Expression system

      Escherichia coli

    • Accession

      Q13291

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMGSASYGTGGRMMNCPKILRQLGSKVLLPL TYERINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYK FYLENLTLGIRESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIK VLNKTQENGTCTLILGCTVEKGDHVAYSWSEKAGTHPLNPANSSHLLSLT LGPQHADNIYICTVSNPISNNSQTFSPWPGCRTDPSETKP

      • Predicted molecular weight

        27 kDa including tags

      • Amino acids

        21 to 237

      • Tags

        His tag N-Terminus

    • Description

      Recombinant Human SLAM / CD150 protein

    Specifications

    Our Abpromise guarantee covers the use of ab139259 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • 4933415F16
      • AA177906
      • CD 150
      • CD150
      • CD150 antigen
      • CDw150
      • Estm51
      • Ipo 3
      • IPO-3
      • Ipo3
      • MGC151472
      • MGC151476
      • OTTHUMP00000025670
      • OTTHUMP00000060252
      • RGD1560634
      • Signaling lymphocytic activation molecule
      • Signaling lymphocytic activation molecule family member 1
      • Signaling lymphocytic activation molecule family member 1, isoform CRA_a
      • Signaling lymphocytic activation molecule family member 1, isoform CRA_b
      • Signaling lymphocytic activation molecule precursor
      • Slaf1
      • SLAF1_HUMAN
      • SLAM family, member 1
      • Slamf 1
      • SLAMF1
      • SLAMF1 protein
      see all

    • Function

      High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

    • Tissue specificity

      Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

    • Sequence similarities

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Domain

      The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.

    • Post-translational
      modifications

      Phosphorylated by FYN.

    • Cellular localization

      Cell membrane. Present on the surface of B-cells and T-cells.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)
      SDS-PAGE - Recombinant Human SLAM / CD150 protein (denatured) (ab139259)
      15% SDS-PAGE analysis of 3 µg ab139259.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab139259? Please let us know so that we can cite the reference in this datasheet.

    ab139259 has not yet been referenced specifically in any publications.

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